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The imbalance of immune checkpoint signaling likely serves as a critical nexus in the cross-talk between ferroptosis and immune dysregulation, highlighting these molecules as potential therapeutic targets for combinatorial interventions targeting the ferroptosisimmunity axis in AD

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C57BL/6J mice (male, 68week-old) were acquired from China Medical University (Liaoning, China)

Further research and carefully designed clinical trials are essential to bridge this gap and determine the true therapeutic potential of UA in treating neurodegenerative diseases in humans

Blood 81 , 22232236 (1993)

Weihl, SQSTM1 splice site mutation in distal myopathy with rimmed vacuoles