MEDI0382, a GLP-1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subject, randomized, Phase 1 study
The most common side effects are gastrointestinal, including nausea (1222%), diarrhea (1316%), vomiting (69%), and constipation (67%)
Product Specifications Peptide: GLP-1/GIP Concentration: 5mg per vial Form: Lyophilized powder Purity: 98% (HPLC Verified) Molecular Formula: C225H348N48O68 Molecular Weight: ~4813.5 g/mol Shelf Life: 36 months if stored properly Storage & Handling Instructions Reconstitute with bacteriostatic water (BAC) Do not shake after reconstitution Store lyophilized peptide at 20C or colder Keep reconstituted solution refrigerated at 28C Protect from light, moisture, and heat Research Applications (Preclinical Use Only) Dual receptor (GLP-1 and GIP) signaling studies Multi-pathway peptide interaction modeling Receptor co-activation and peptide stability research Preclinical endocrine system investigation Synthetic peptide pathway analysis All applications are limited to controlled laboratory research environments
[46] Enebo, L
Some patients say semaglutide made them feel more anxious or depressed A review of real-world data from healthcare databases and registries is underway
Subramaniam, S., Joyce, P., Thomas, N