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doi: 10.3389/fphar.2021.632295 Received 07 December 2020 Accepted 13 April 2021 Published 10 June 2021 Volume 12 - 2021 Edited by Chiara Bianca Maria Platania, University of Catania, Italy Reviewed by Doreen Schmidl, Medical University of Vienna, Austria Francesca Lazzara, University of Catania, Italy Updates Copyright 2021 Zlatar, Kokot, Vuletic, Masnec, Kralj, Perisa, Barisic, Radic, Milanovic, Drmic, Seiwerth and Sikiric

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Rheum officinale (Dahuang), traditionally used for detoxification, reduces neuroinflammation and apoptosis while facilitating neurogenesis and tissue repair 64

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Methylation levels at two positions in the promoter region of the MGMT gene were quantitatively analyzed using a combination of COBRA and native capillary gel electrophoresis ( 2.3 PacBio SMRT sequencing PacBio SMRT sequencing is a third-generation methylation assay

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So there are so many complicating factors, and I just commend you for trying to at least shed some light on this complicated issue that I think practitioners tend to simplify just because otherwise, it's too overwhelming to treat to be honest

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