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Those who have known gastrointestinal disorders, chronic symptoms of abdominal bloating, constipation, or diarrhea, pernicious anemia, or low stomach acid will have issues with absorption and should instead consider B12 injections which allow for the highest absorption of B12 into your system

ACS Chemical Neuroscience

Ordonez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, Fahy JV

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Often, their disease is only diagnosed at the end stage, and many of the reported reactions to B12 are consistent with the disease itself