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It also causes: Reduced growth hormone and thyroid-Stimulating Hormone (TSH) levels Hyperinsulinemia with insulin resistance Dyslipidemia Severe degrees of hepatic steatosis Absence of secondary sexual development with hypogonadotropic hypogonadism Occasionally, immune deficiency resulting in severe and repeated bacterial infections that may be fatal early in life Related Stories GLP-1 weight-loss drugs may also reduce binge eating Smelling dark chocolate before training may improve workout performance Study links GLP-1 treatment to fewer alcohol drinking days There are eight different homozygous leptin gene mutations which can lead to leptinopenia