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Both pathway and individual metabolite analysis revealed differential abundance of tryptophan pathway intermediates in PBH, including tryptophan itself and its downstream metabolites kynurenic acid, xanthurenate, and serotonin (Figure 4)

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In the normal tissues, a large number of red-stained chondrocytes and cell stroma were observed in the NP, while a significant reduction was found in patients who underwent PELD