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165 LRP6 is downregulated in the AD brain, and deficiency in LRP6-mediated Wnt/-catenin signalling contributes to synaptic dysfunction and amyloid pathology in AD

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It appears to be a potent stimulator of both GH and IGF-1 to an extent comparable with exogenous GH therapy, and it has a significant impact on body composition

The trial found it was well tolerated with injection site reactions as the most common side effect