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The next frontier of GLP-1s GLP-1s have been hailed as one of the biggest breakthroughs in weight-loss medicine in decades, and their reach is only expected to grow as more convenient and potentially more powerful versions hit the market

For a broader context on the roles of SGLT2 and GLP1 agents in cardiometabolic care, the American Diabetes Associations Standards of Care provide neutral guidance on riskbased selection (American Diabetes Association publications offer yearly updates)

Third, it raises questions about the optimal duration of therapy and whether intermittent dosing might maintain benefits

Badve SV, Bilal A, Lee MMY et al (2025) Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: a meta-analysis of randomised controlled trials

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