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The magnitude of the NAD + -elevation effect of NNMT inhibition in vivo, and its contribution to the metabolic phenotype relative to the methylation effects, remains an active area of research

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2 It also helps support against the age-related increase in oxidative stress and the decrease in mitochondrial efficiency that occurs with advancing years

In contrast, for most other patient characteristics assessed in our study, the associations with treatment discontinuation were similar for SGLT2 inhibitors and GLP-1 receptor agonists