The concept of the gut-brain-ear axis has emerged, linking imbalances in the gut microbiota (dysbiosis) to the development of hearing loss 38 , exposure to environmental noise stress 39 , and chronic tinnitus 28
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Spermidine-mediated induction of autophagy requires that the pro-autophagic transcription factor identified as TFEB (transcription factor EB, where the EB refers to enhancer box binding site) be activated
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity
Some patients have sought treatment at the ER
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