Recent studies indicate an alternate role of GNE in cell apoptosis and adhesion, besides SA biosynthesis
Glutathione can also be administered through intramuscular injection or intravenous vitamin infusion therapy (IV therapy)
High glutathione levels are uncommon but may be associated with resistance to chemotherapy, elevated white blood cells, and myelofibrosis
Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
Patients often exhibit fever, lymphadenopathy, splenomegaly, hepatitis, or pancytopenia
Critically, a compensatory mtDNA maintenance mechanism present in healthy aging brains is impaired, leading to progressive mtDNA depletion and respiratory chain failure [90]