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The presence of cell surface receptors allows another process called receptor-mediated transcytosis (RMT) , notably used for the transport of large molecular weight molecules [ Figure 3 (D) ]
Nonetheless, whether the specific mechanism of this is related to the transdifferentiation of VSMCs to a bone-like phenotype, loss in SMC lineage markers, enhanced pro-calcific microRNAs, increased intracellular calcium level, apoptosis, or aberrant DNA damage response (DDR) requires further investigation
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