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These changes are generally indirect rather than a direct pharmacological effect of semaglutide or tirzepatide on reproductive hormones
suggests that a key element in this process involves the activation of G-proteins, which are closely associated with the inner surface of the cell membrane and activate downstream pathways leading to the production of secondary messengers such as cyclic adenosine monophosphate (cAMP) and inositol triphosphate (IP3)
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Tang, L., Fatehi, M