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This conversion requires several enzymatic steps

Two established human GLP1 targets, the duodenal Brunner glands (Figure 1ad) and the pancreatic islets (Figure 1eh), known to be GLP1R positive with receptor autoradiography, are also found GLP1R positive by immunohistochemistry (Figure 1a and e)

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For individuals with compromised digestion, such as those suffering from the gastrointestinal symptoms seen with Long COVID, the inability to fully break down these resilient proteins creates a significant physiological burden