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is widely used in food and feed, its ability to harbor virulence factor and inherent antimicrobial resistance raises significant safety concerns

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Diabetes Care 33 , 18341836 (2010)

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They are now commonly used when: Metformin alone is no longer enough Weight gain is contributing to worsening glucose control There is a need to minimise hypoglycaemia risk Someone has existing cardiovascular disease or multiple risk factors For many people, GLP-1 therapy can delay or reduce the need for insulin, or allow insulin doses to be kept lower and safer