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In the APP/PS1 model, somatostatin (SOM) interneurons near amyloid plaques become hyperactive, while parvalbumin interneurons are hypoactive, leading to an excitation-inhibition imbalance (Michaud et al., 2024)

AACE and ACE recommend initiation of weight-loss medications for patients with a BMI of 27 mg/kg 2 or greater after failing an adequate trial of lifestyle interventions

Van Biesen, W., Lameire, N., Vanholder, R

Alternative RNA processing of the primary transcript by inclusion of exons 1 to 4 with polyadenylation following exon 4 (encoding calcitonin) produces a mRNA that encodes the precursor for calcitonin

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(10(2)):7705 doi:10.4081/pr.2018.7705