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Others rely on flashy packaging and borrowed credibility from actual GLP-1 medications to sell products that have never been tested in clinical trials

Emerging evidence shows GLP-1R activation reduces systemic inflammation (hsCRP, IL-6) and oxidative stress independent of weight loss

Notably, IGF-1 LR3 enhances muscle sensitivity to insulin, thereby promoting glucose uptake and utilization while simultaneously reducing fat storage

Metformin: still first-line for most adults How it works: Metformin reduces the amount of glucose released by the liver, modestly improves insulin sensitivity in muscle and fat, and slows intestinal glucose absorption

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These outcomes illustrate a clear doseresponse curve for weight management, where escalating weekly dosing correlates strongly with greater body weight reduction