One critical factor in timeline is the management of die-off reactions, known clinically as the Herxheimer reaction: as Candida organisms are killed, they release toxins that can temporarily worsen symptoms including headaches, fatigue, and joint pain
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The people who run into trouble are those who started closer to the lower end of normal, around 200-300 pg/mL, where even a modest decline pushes them into deficiency
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No oral or topical therapy has been shown to be efficacious when administered alone, but some evidence supports their use as part of a combination therapy regimen
This is sometimes referred to as fight or flight. But when the stress becomes chronic, kidney function changes, nutrient depletion may occur, and the adrenal glands may not have what they need to continue functioning optimally