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The MTX group showed significant elevations in hepatic ATF4 and GRP78 versus the CTRL group

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Furthermore, since post-inflammatory hyperpigmentation can occur in patients with lichen sclerosus, and the latter disease is a risk factor for squamous cell carcinoma or melanoma [27, 28, 31], skin biopsies are often required in these patients to accurately diagnose the nature of the hyperpigmentation

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