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GCH1 protects cells from ferroptosis mainly through the antioxidant effects of BH4/BH2, utterly independent of gpx4-mediated ferroptosis

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Secondly, GLP-1 receptor agonists carry important safety considerations including risk of pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (based on rodent studies, though human relevance remains uncertain)

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