[86] found that semaglutide, as a GLP-1 analog, can directly act on fat cells, increase the expression of thermogenic genes for browning phenotype maintenance, improve the expression of UCP1, mitochondrial biosynthesis and thermogenic marker, thereby contributing to weight loss
doi:10.1097/fbp.0000000000000818 16.Garvey WT, Blher M, Osorto Contreras CK, et al
Kojic Acid: Known for its skin lightening effects, Kojic Acid helps to fade hyperpigmentation, age spots, and sun damage, revealing a more luminous and even-toned complexion
For example, tretinoin accelerates the turnover of aging skin cells while stimulating the generation of fresh ones
However, there are caveats
Summary: Combination therapy with GLP-1 receptor agonists and SGLT2 inhibitors uses two distinct drug classes simultaneously to improve glycaemic control in type 2 diabetes through complementary mechanisms whilst providing cardiovascular and renal protection