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Fig.6 WuXi Biology Liver Disease Models References Abdelmalek M F, Harrison S A, Sanyal A J

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In addition, there are a group of NOX (NADPH oxidases) enzymes located on the cell membrane of polymorphonuclear cells, macrophages and endothelial cells, that facilitate the conversion of oxygen into superoxide on biological membranes using NADPH as an electron donor with ROS released as secondary products (Figure 1)