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337 The choice of hypoglycemic agents for initial monotherapy should be personalized considering the need to reduce MDS-related TOD, such as weight management and comorbidities, as demonstrated above

ESRRA (estrogen-related receptor ) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense

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All mice received 2 days of 10 mL/kg body weight sterile saline subcutaneous injections before beginning the treatment phase to allow for acclimation to the handling and stress associated with injections