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RE Patterson, GA Laughlin, AZ LaCroix, et al

The direct, quantified, longitudinal human measurements that would settle it are largely absent from the published cagrilintide monotherapy literature, and there is a credible mechanistic reason the tendency of long-acting gut-hormone agonists toward gastric-emptying tachyphylaxis, plus obesity-associated amylin-receptor down-regulation to suspect the gastric arm may attenuate even as central satiety persists

Others, like tirzepatide, also mimic GIP (glucose-dependent insulinotropic polypeptide) for additive effects

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Many report results in as little as 7-10 days, but it varies on your unique biology