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Medications include brand-name Wegovy, compounded semaglutide, and brand-name Zepbound via insurance (see our tirzepatide vs semaglutide breakdown)

The products only share one active ingredient, though, and Vertex said the combination of drugs used in Alyftrek has benefits over Trikafta, which generated sales of $8.9 billion in 2023

However, newer drugs like tirzepatide (Mounjaro or Zepbound) appear to have similar rates of gastrointestinal side effects compared to semaglutide