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In the next experiment, buthionine sulfoximine (BSO, 10mM), the inhibitor of gammaglutamylcysteine synthetase was added during 24 hours to A549 cell culture (Figure 4)

GSH depletion and copper-catalyzed oxidation of catecholamines generate toxic quinones and ROS, which synergistically contribute to cuproptosis [3]

Comparison of protein carbonyl and total plasma thiol concentrations in patients with complete hydatidiform mole with those in healthy pregnant women

Garte S, Gaspari L, Alexandrie AK, Ambrosone C, Autrup H, et al: Metabolic gene polymorphism frequencies in control populations