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These findings suggest that GLP-1RAs may target GLP-1R in EAT to regulate local adipogenesis, energy utilization, and cellular phenotype, thereby influencing cardiovascular health (Figure 2)

Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and/or chronic kidney disease: design and baseline characteristics of soul, a randomized trial

What makes Orforglipron unique compared to injectable GLP-1 drugs

Processed foods and screen-time are also highly addictive to the human brain

GLP-1 acts as a satiety hormone [21], transmitting signals of fullness from the gut to the brain and activating GLP-1R mediated by paracrine activations of vagus afferent neurons innervating the gastrointestinal tract [22, 23]

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