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The acyl-CoA synthetase short-chain family members (ACSSs) can convert short-chain fatty acids into short-chain acyl-CoA, and the acetic acid, transported into tumor cells, is mainly catalyzed by nuclear-cytoplasmic localized ACSS2, rather than mitochondrial-localized ACSS1, ACSS3, to produce acetyl-CoA [48]

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The type of heart failure the Hopkins' study focused on was "heart failure with preserved ejection fraction" (HFePF)

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