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When paired with GLP-1like in dual agonists such as tirzepatide and the triple agonist retatrutideit becomes a powerful driver of weight loss, improved glucose control, and insulin sensitivity
This hypothesis is supported by Seahorse analysis, which revealed that CI inhibition by Rot treatment significantly reduced basal respiration, ATP-linked respiration, maximal respiration, and spare respiratory capacity, but not proton leak (Fig
In terms of glycemic control, these agents affect glucose metabolism through distinct pathways: GLP-1RAs enhance glycemic control by stimulating glucose-dependent insulin secretion, while SGLT2is lower blood glucose levels by inhibiting glucose reabsorption in the proximal renal tubules, leading to increased urinary glucose excretion
[DOI] [PMC free article] [PubMed] [Google Scholar] [39].Zhao L, Han Y, Wang Y, Ke T, Huang S
Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ(r))-Patient Version
