How the insect pathogen bacteria Bacillus thuringiensis and Xenorhabdus/Photorhabdus occupy their hosts
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In the enzymatic pathway, the lipoxygenase (LOX) family plays a central role: ALOX12 is essential for p53-mediated ferroptosis and serves as a key effector downstream of solute carrier family 7 member 11(SLC7A11) ( 2.2.3 Coordinated regulation by signaling pathways In periodontitis, aberrant activation of the Hippo-YAP pathway promotes iron accumulation and lipid peroxidation synergistically by upregulating TFRC and ACSL4 while downregulating GPX4, thereby accelerating ferroptosis-induced periodontal tissue damage ( Clinical evidence indicates that gingival tissue biopsies from periodontitis patients show significantly upregulated ACSL4 protein expression, and gingival crevicular fluid exhibits abnormally elevated concentrations of 4-HNE and MDA
Cullinan, S
After staining for 15 min, blood samples were proceeded to erythrocyte lysis with FACS TM lysing solution, washed twice with FW, and measured by flow cytometry and analyzed with FlowJo X