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Patients on metformin and another antihyperglycemic agent (N=229) and patients not on any antihyperglycemic agents (off therapy for at least 8 weeks, N=41) were randomized after a run-in period of approximately 10 weeks on metformin HCl (at a dose of at least 1500 mg per day) in monotherapy

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Deciding which medication is right depends on individual health status, treatment goals, and medical advice

Other important adverse effects include: Acute pancreatitis : Severe, persistent abdominal pain radiating to the back requires immediate medical attention

Both are pharmacologically active compounds with documented effects on the cardiovascular system, the gastrointestinal tract, and metabolic regulation

Some patients may benefit from more frequent injections initially, followed by maintenance shots