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Circulation 144 , 805822 (2021)

doi:10.1016/j.clinbiochem.2021.04.023

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Compared with the rats treated with APAP alone, rhein treated animals demonstrated significant reduction of the biochemical indicators of liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen (UREA), creatinine (CREA), nitric oxide (NO), and malondialdehyde (MDA)

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In fact, glutathione is one of the body's primary antioxidants and plays a role in protecting cells from oxidative damage, which is generally protective rather than carcinogenic