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Most leaky gut supplements include L-glutamine, which people with a history of liver or kidney disease shouldnt take.58 Adding glutamine to your daily routine can worsen mental health symptoms such as psychosis, so if you have a history of psychiatric conditions, be cautious when starting a leaky gut supplement.59 Glutamine can also interfere with anti-epileptic medications and epilepsy in general.60 Probiotics are generally safe for most people to take, but as with any supplement, you should reach out to your doctor before beginning a new regimen