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Supplementary material The Supplementary Material for this article can be found online at: References 1 MacintoshMCMFlemingKMBaileyJADoylePModderJAcoletDet al

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In addition, dysregulated -KG flux from normal reductive anabolism via the TCA cycle toward R-2-HG production has been associated with other metabolic flux impairments and disrupted redox balance 119,120 (Fig