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LDL cholesterol, another major heart risk marker, decreases as well, but this can be more personalized

PMID: 352809314

Mir Ali, a bariatric surgeon at Orange Coast Medical Center, explains: "Consuming a high amount of calories can still lead to weight gain or a plateau, even on these medications

The gradual dose increase is specifically designed to help minimise these effects

Nearly half achieved 15% or greater weight loss, approaching surgical outcomes without any operative intervention

These protective effects on beta cells are considered to exert through alleviating gluco- and lipo-toxicity indirectly, but the direct positive effect of metformin on -cells is not generally accepted 44