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Primary Handling Editors: Ashley Castellanos-Jankiewicz, Liam Messin and Sonia Muliyil, in collaboration with the Nature Medicine team

When exposed to freezing temperatures, water in the solution expands and forms ice crystals that physically rupture the delicate peptide structure, denaturing the molecule

This means that it is safe for more people, especially those with high blood pressure, sleep issues, anxiety and more

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However, the triple-hormone receptor agonism of retatrutide may bring additional benefits, potentially leading to more improvements in these parameters