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While melatonin has a direct effect on oxidative stress by scavenging ROS and RNS (1), its metabolites (product of its degradation) are also active and act indirectly by inducing the production of anti-oxidative enzymes and lowering the synthesis of pro-oxidative molecules (2) leading to an overall reduction of oxidative stress

HCV NS5B polymerase was incubated with HCV3END10A RNA in the presence of FAD and CTP, complemented with 32 P-labeled CTP for visualization

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