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Semaglutide targets one receptor (GLP-1), while tirzepatide targets two (GIP + GLP-1)

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There was no change in cognitive parameters in the follow-up assessment compared to controls [325]

Phase 2 trial results, published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023), demonstrated that participants receiving the highest dose of retatrutide lost an average of approximately 24% of their body weight over 48 weeks a finding that attracted considerable attention from the medical and scientific communities

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