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Conclusion: Altogether, our results show that the cellular antioxidant defense systems contribute to leukemia resistance to MTX, and targeting these pathways, especially the thioredoxin antioxidant system, may be a promising strategy for resensitizing ALL to MTX

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The Two States of Glutathione While L-glutathione and reduced glutathione are the same, glutathione itself exists in a constant cycle between two different states

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The cytoplasmic-nuclear shuttling of -catenin is considered an important feature of Wnt/-catenin pathway activation