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doi: 10.1016/j.dsx.2018.03.002 94 OrskovCWettergrenAHolstJJ

Various metabolites of MDMA including potentially toxic quinone and thioester compounds may directly or indirectly interfere with the mitochondrial electron transport system, leading to increased leakage of ROS from the mitochondria

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The peptides mechanism (competitive inhibition of FOXO4-p53 binding) does not produce tolerance or require gradual dose increases

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