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the total number of actin enriched spines adjacent to VGLUT1 or Synapsin were counted and converted to a percentage as the percent correlation of treatment-induced spines to presynaptic markers is a strong indicator of ability to transmit excitatory signals
This was reported in 4.9% of people taking the tablet, compared to 0% on placebo
We know from structural studies that due to its tetrameric nature, p53 requires a certain number of WT subunits to maintain functionality [35], and that many pathogenic p53 variants exhibit a dominant negative effect
Care 18 , e1e14 (2012)