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Meta-analyses of randomized trials corroborate these findings: one large review of 27 RCTs reported no significant difference in suicidality between GLP-1 RAs and placebo (RR 0.76) [48], while another meta-analysis including 25 trials similarly showed no association across multiple subgroups and endpoints (RR 0.84) [49]
Use: In combination with a reduced calorie diet and increased physical activity, to reduce excess body weight and maintain weight reduction long term in patients with obesity, or in patients with overweight in the presence of at least 1 weight-related comorbid condition Usual Adult Dose for Cardiovascular Risk Reduction ORAL: Ozempic Tablets: Initial dose (initiation phase
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