retatrutide triple agonist glp-1 gip glucagon phase 2 trial obesity Retatrutide, the triple-G (GLP-1, GIP, and receptor) caused patients with and knee osteoarthritis to lose an average of 23.7% of body weight after 68 weeks, according to the results The TRIUMPH-1 Phase 3 results

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Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from approved single or dual agonists such as semaglutide and tirzepatide

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This suggests that nutrient-induced GLP-1 secretion was inhibited by pasireotide via SSTR-Gi-dependent inhibition of cAMP levels