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Reducing lean mass can have several negative effects on the body, including slowing metabolism, reducing strength and endurance, and increasing the risk of injury

In a head-to-head trial against semaglutide (the SURPASS-2 trial), tirzepatide produced significantly greater weight loss, with participants taking the highest dose of tirzepatide losing an average of 11.2 kg (24.7 lbs), compared to 5.7 kg (12.5 lbs) for those taking semaglutide 1 mg

Other recent studies have shown the drugs help people with obesity lower their high blood pressure and reduce their odds of heart attacks or strokes

Subcutaneous tissue here tends to be thinner than abdomen or thigh, making needle length selection and pinch technique more important

In addition, studies of bariatric surgery in overweight or obese individuals versus matched controls also showed decreased incidence of obesity-related cancers and decreased cancer-related mortality

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