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40 Oral semaglutide: safety and efficacy data from trials A Phase II, 26-week randomized multicenter, open-label clinical trial, in which oral semaglutide was compared with subcutaneous semaglutide and placebo, was designed and finally recruited 1106 participants

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The tirzepatide dose groups and regimens were as follows: 12 mg (4 mg for weeks 0-3, 8 mg for weeks 4-7, and 12 mg for weeks 8-11), 15 mg-1 (2.5 mg for weeks 0-1, 5 mg for weeks 2-3, 10 mg for weeks 4-7, and 15 mg for weeks 8-11), and 15 mg-2 (2.5 mg for weeks 0-3, 7.5 mg for weeks 4-7, and 15 mg for weeks 8-11)