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Use backup contraception methods like condoms for at least 4 weeks after starting Retatrutide and after each dose increase

Although GLP-1RAs improve mobility and reduce body weight, some patients decrease physical activity during treatment due to fatigue or altered energy perception

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Key warning signs requiring urgent evaluation include: Postmenopausal bleeding (any vaginal bleeding occurring more than 12 months after the last menstrual period) Bleeding accompanied by fever, unusual vaginal discharge, or pelvic pain suggesting infection Bleeding associated with pregnancy or suspected pregnancy Recurrent spotting that persists for more than two to three menstrual cycles Patients taking tirzepatide who develop abnormal bleeding should undergo a comprehensive gynecological assessment, including detailed menstrual history, pelvic examination, and pregnancy testing for all reproductive-age women regardless of contraceptive use

And for many, it creates fear

Kort DH, Lobo RA