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When people (and mice) consume L-carnitine, the scientists found, certain microbes in the gut step in and metabolize the compound, creating another chemical known as trimethylamine-N-oxide, or TMAO -- which, in turn, seems to play a key role in promoting cardiovascular disease by altering the way the body processes cholesterol

A methionine residue oxidizes

Clifford says

This information can support a more informed conversation with your rheumatologist about whether GLP-1 treatment aligns with your genetic and inflammatory profile