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This results in the accumulation of Ang II, which increases aldosterone secretion, resulting in subsequent hypokalemia, which inhibits insulin secretion (35) and exerts vasoconstriction, oxidative stress, inflammation, fibrosis, and pulmonary edema by combination with the AT1 receptor (AT1R)

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doi: 10.1128/JB.185.18.5555-5562.2003 238 VesikariT.ForstenA.SeppI.KaijalainenT.PuumalainenT.SoininenA.et al

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Writing Group for the DCCT/EDIC Research Group, Orchard TJ, Nathan DM, Zinman B, Cleary P, Brillon D, et al