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A broader methodological review reports that SUMO proteases maintain high cleavage fidelity across diverse conditions, temperature (437 C), pH (5.510.5), detergents, 2 M urea, tolerate various fusion partners, and rarely show off-target cleavagethough they cannot cleave proteins containing N-terminal proline immediately following the SUMO fusion [72,145]
By protecting the mitochondria, glutathione may also help to manage inflammation and ward against more serious autoimmune conditions