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Randomization was carried out using a minimization approach [Pocock and Simon (1975)] using the following factors: gender, ECOG PS (0 versus 1), response to prior chemotherapy (complete or partial response versus stable disease), history of brain metastases (yes versus no), non-platinum component of induction therapy (docetaxel versus gemcitabine versus paclitaxel), and disease stage (IIIb versus IV)

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One article proposed that GHK-Cu, by virtue of its copper-binding and gene-modulatory potential, might help reverse oxidative stress and inflammation associated with time passing or tissue damage

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10.1016/j.freeradbiomed.2011.08.031 Free Radic Biol Med